Antisense Drug Technology: Principles, Strategies, and - download pdf or read online

By Stanley T. Crooke

ISBN-10: 0824705661

ISBN-13: 9780824705664

largely revised and up-to-date, Antisense Drug know-how: rules, thoughts, and functions, moment Edition displays the logarithmic development made some time past 4 years of oligonucleotide-based treatments, and, specifically, antisense therapeutics and examine. reading classes realized from the medical trials of first iteration medications, the booklet evaluates the expertise as an entire and provides new instructions and avenues of study and improvement.

Divided into 5 components, the booklet starts with an intensive advent to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the aptitude therapeutics of splice switching oligonucleotides. prime researchers exhibit the fundamentals of oligonucleotide therapeutics partially through delineating medicinal chemistry, pharmacokinetics, and supply routes corresponding to liposomal formulations for nucleic acid delivery.  half 3 info hybridization dependent medicines and considers the dramatic advances represented by means of 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medications. different chemical sessions of gear and mechanisms of motion are defined partly 4 with additional discussions on enhancing the second one new release antisense medicinal drugs. the ultimate half delves deeply into healing functions. Contributing authors learn the potential for antisense medications for the relief of cardiovascular ailments, metabolic ailments, inflammatory ailments, melanoma, neurological issues, and immune modulation.

Presenting a hugely certain, lucid dialogue of the amazing advances within the box, Antisense Drug know-how: ideas, techniques, and functions, moment Edition presents the platform for researchers to proceed to aggressively pursue the nice chance represented by means of this fascinating technology.

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Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition by Stanley T. Crooke

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